منابع مشابه
Atomistic protein folding simulations on the submillisecond time scale using worldwide distributed computing.
Atomistic simulations of protein folding have the potential to be a great complement to experimental studies, but have been severely limited by the time scales accessible with current computer hardware and algorithms. By employing a worldwide distributed computing network of tens of thousands of PCs and algorithms designed to efficiently utilize this new many-processor, highly heterogeneous, lo...
متن کاملFast events in protein folding initiated by nanosecond laser photolysis.
Initiation of protein folding by light can dramatically improve the time resolution of kinetic studies. Here we present an example of an optically triggered folding reaction by using nanosecond photodissociation of the heme-carbon monoxide complex of reduced cytochrome c. The optical trigger is based on the observation that under destabilizing conditions cytochrome c can be unfolded by preferen...
متن کاملHierarchy of events in protein folding: beyond the Go model
Simplified Gō models, where only native contacts interact favorably, have proven useful to characterize some aspects of the folding of small proteins. The success of these models is limited by the fact that all residues interact in the same way, so that the folding features of a protein are determined only by the geometry of its native conformation. We present an extended version of a C α base...
متن کاملEarly events in protein folding explored by rapid mixing methods.
2.1. Turbulent Mixing 1838 2.2. Stopped-Flow Methods 1838 2.3. Continuous-Flow Techniques 1839 3. Detection Methods 1841 3.1. Tryptophan Fluorescence 1841 3.2. ANS Fluorescence 1842 3.3. Fluorescence Energy Transfer 1842 3.4. Continuous-Flow Absorbance 1843 3.5. Probes of Secondary Structure Formation 1844 3.6. Small-Angle X-ray Scattering 1844 3.7. Other Detection Methods 1844 4. Quenched-Flow...
متن کاملEarly events in RNA folding.
We describe a conceptual framework for understanding the way large RNA molecules fold based on the notion that their free-energy landscape is rugged. A key prediction of our theory is that RNA folding can be described by the kinetic partitioning mechanism (KPM). According to KPM a small fraction of molecules folds rapidly to the native state whereas the remaining fraction is kinetically trapped...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.23.10668